Qualitative states of hydrolysis

20 November 2017 - Qualitative reasoning applied to cellulose hydrolysis

20 November 2017 - Qualitative reasoning applied to cellulose hydrolysis

With the accumulation of scientific information in publications, even experts can find difficult to keep integrating new piece of information and results for modelling. The approach we propose aims at constructing mechanistic explanation from selected scientific papers using the Qualitative Reasoning framework.

As a proof of concept, we have applied the approach to modelling articles about cellulose hydrolysis mechanism, which is not fully understood, focusing on the causal explanations for the decreasing of hydrolytic rate. Through a project lead by BIA INRA lab and involving FARE lab and Amsterdam University, two explanatory qualitative reasoning models were built to capture classical explanations for the phenomenon. Our results show that none of them provides sufficient explanation for a set of basic experimental observations described in the literature. Combining the two explanations into a third one allowed to get a new and sufficient explanation for fitting the experimental results.

Contact: Dr Kamal Kansou, kamal.kansou@inra.fr

Read: Kansou K, Rémond C, Paës G, Bonnin E, Tayeb J, Bredeweg B. Testing scientific models using Qualitative Reasoning: application to cellulose hydrolysis. Scientific Reports 2017, 7, 14122. DOI

Modification date : 06 June 2023 | Publication date : 20 November 2017 | Redactor : G. Paës